Table 13 Summary of relevant CSF findings in neuropsychiatric lupus
From: S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)
| Parameter | Diagnostic LP | Follow-up LP (under immunosuppressive treatment) | Remarks |
|---|---|---|---|
| Cell count | 1-400/μL in 30 to 44% of patients | ||
| Cell type | Lymphocytes, monocytes | ||
| Albumin ratio | < 8 × 10−3: 60% 8-25 × 10− 3: 40% | ||
| Quantitative IgG-, IgA-, IgM-synthesis | IgG > 0%: 30% IgA > 0%: 13% IgM > 0%: 17% | ||
| OCB | Type 2 or 3: 30% | Change to type 1 or 4 possible | |
| MRZ reaction AI ≥1.5 | Measles: 30% Rubella: 30% Zoster: 40% | Intrathecal dsDNA antibodies in 20% |